A 10-day mild treadmill exercise performed before an epileptic seizure alleviates oxidative injury in the skeletal muscle and brain tissues of the rats

Objective: Epileptic seizures may cause skeletal muscle injury and memory dysfunctions. The present study was aimed to investigate the possible protective effects of exercising prior seizure on seizure-induced oxidative in brain. Materials Methods: Sprague-Dawley male rats were assigned as non-exercise (n=16) exercise groups (n=16). Following a 3-day training, protocol (30 min) performed treadmill for 10 days, while control had no exercise. On 11th day epileptic induced by single intraperitoneal injection pentylenetetrazol (PTZ) (45 mg/kg), injected with saline. Passive-avoidance test initially before PTZ/saline repeated 72 h later assessment function. Brain gastrocnemius muscles taken histological assessments determine levels malondialdehyde (MDA) glutathione (GSH), myeloperoxidase (MPO) activity luminal -and lucigenin- enhanced chemiluminescence levels. Results: Exercise training alone increased formation reactive oxygen species elevated antioxidant GSH capacity tissue rats, but these not observed exercised PTZ-seizure. other hand, short-term effect basal parameters brain tissues. Prior did alter average scores or performances when compared non-exercised groups, suppressed PTZ-induced elevations MDA well MPO Conclusion: A 10-day mild reduced damage due excitotoxicity exerted preconditioning exposed tonic-clonic contractions.